35,751 research outputs found

    Towards the timely detection of toxicants

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    We address the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, recently invented for the specific purpose of studying non-stationary time series. We study the specific case where the toxicant is tetrodotoxin. This is a very poisonous substance that yields an abrupt drop of the rate of spike production at t approximatively 170 minutes when the concentration of toxicant is 4 nanomoles. The CASSANDRA algorithm reveals the influence of toxicants thirty minutes prior to the drop in rate at a concentration of toxicant equal to 2 nanomoles. We argue that the success of this method of analysis rests on the adoption of a new perspective of complexity, interpreted as a condition intermediate between the dynamic and the thermodynamic state.Comment: 6 pages and 3 figures. Accepted for publication in the special issue of Chaos Solitons and Fractal dedicated to the conference "Non-stationary Time Series: A Theoretical, Computational and Practical Challenge", Center for Nonlinear Science at University of North Texas, from October 13 to October 19, 2002, Denton, TX (USA

    MEG sensor and source measures of visually induced gamma-band oscillations are highly reliable

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    High frequency brain oscillations are associated with numerous cognitive and behavioral processes. Non-invasive measurements using electro-/magnetoencephalography (EEG/MEG) have revealed that high frequency neural signals are heritable and manifest changes with age as well as in neuropsychiatric illnesses. Despite the extensive use of EEG/MEG-measured neural oscillations in basic and clinical research, studies demonstrating test–retest reliability of power and frequency measures of neural signals remain scarce. Here, we evaluated the test–retest reliability of visually induced gamma (30–100 Hz) oscillations derived from sensor and source signals acquired over two MEG sessions. The study required participants (N = 13) to detect the randomly occurring stimulus acceleration while viewing a moving concentric grating. Sensor and source MEG measures of gamma-band activity yielded comparably strong reliability (average intraclass correlation, ICC = 0.861). Peak stimulus-induced gamma frequency (53–72 Hz) yielded the highest measures of stability (ICCsensor = 0.940; ICCsource = 0.966) followed by spectral signal change (ICCsensor = 0.890; ICCsource = 0.893) and peak frequency bandwidth (ICCsensor = 0.856; ICCsource = 0.622). Furthermore, source-reconstruction significantly improved signal-to-noise for spectral amplitude of gamma activity compared to sensor estimates. Our assessments highlight that both sensor and source derived estimates of visually induced gamma-band oscillations from MEG signals are characterized by high test–retest reliability, with source derived oscillatory measures conferring an improvement in the stability of peak-frequency estimates. Importantly, our finding of high test–retest reliability supports the feasibility of pharma-MEG studies and longitudinal aging or clinical studies

    Photodiagnostics of turbulent flows using laser-induced fluorescence

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    An optical probe technique that will allow remote measurements of temperature (and density), along with their time dependent fluctuations, to be made in a supersonic turbulent wind tunnel flow was developed. Laser-induced fluorescence from nitric oxide which was seeded into the flowing gas medium (nitrogen) at low concentrations was used. The fluorescence emission intensity following laser excitation of the nitric oxide (NO) ground state rotational levels is then related to thermodynamic quantities of the bulk fluid

    Self-phase-locked frequency-by-two divider OPO with a residual fractional frequency instability of 8.1O(-18)

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    We directly measure the phase difference between the subharmonic waves of a self-phase-locked frequency by-2-divider OPO using a phase-sensitive detector scheme. The relative frequency instability of frequency division by 2 is measured to be 8.10(-18

    Two-pion exchange potential and the πN\pi N amplitude

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    We discuss the two-pion exchange potential which emerges from a box diagram with one nucleon (the spectator) restricted to its mass shell, and the other nucleon line replaced by a subtracted, covariant πN\pi N scattering amplitude which includes Δ\Delta, Roper, and D13D_{13} isobars, as well as contact terms and off-shell (non-pole) dressed nucleon terms. The πN\pi N amplitude satisfies chiral symmetry constraints and fits πN\pi N data below ∼\sim 700 MeV pion energy. We find that this TPE potential can be well approximated by the exchange of an effective sigma and delta meson, with parameters close to the ones used in one-boson-exchange models that fit NNNN data below the pion production threshold.Comment: 9 pages (RevTex) and 7 postscript figures, in one uuencoded gzipped tar fil
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